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  • Chlorhexidine(双氯苯双胍己烷)
  • Chlorhexidine(双氯苯双胍己烷)

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Performance and Use: 

Chlorhexidine, also known as chlorhexidine, is a cationic surfactant, which has a strong broad-spectrum antibacterial and bactericidal effect. It is a better bactericidal and disinfectant, and has a stronger antibacterial effect on Gram-positive and Gram-negative bacteria than benzalkonium bromide. It has a positive charge and is adsorbed on the plaque with a negative charge and the surface of the oral mucosa during oral mouthwash. Then the adsorbed drugs diffuse from these parts and gradually separate out to produce a continuous effect until the concentration in saliva decreases 24 hours later. The product is adsorbed on the osmotic barrier of the bacterial plasma membrane to make the cell content leak out. It has a bacteriostatic effect at low concentration and a bactericidal effect at high concentration. Even in the presence of serum, blood, etc. It has no effect on spores, acid fast bacilli, fungi and viruses. It is used to wash hands, soak hands, disinfect the chemical Book skin in the operation area before operation, disinfect the environment such as oral cavity, throat infection, wound washing, instrument disinfection, ward or operating room. Cream or ointment is used for infantile eczema, small area burn, scald and pustule; powder is used for prickly heat, eczema, dermatitis and erythema. The coating is used for light burns and scalds. Chlorhexidine hydrochloride, chlorhexidine acetate and chlorhexidine gluconate are formed by combining chlorhexidine hydrochloride with hydrochloric acid, acetic acid and gluconic acid. At present, chlorhexidine acetate is commonly used in clinical practice in China, but chlorhexidine gluconate is mainly used in clinical practice in the United States, Europe and other countries, especially in the last 10 years, the international research reports on chlorhexidine gluconate are mainly concentrated on chlorhexidine gluconate. Chlorhexidine hydrochloride has low solubility in water, and its preparation mainly consists of plaster and film, which has been basically eliminated in practical use.

Technical index:

CAS No(CAS号).: 55-56-1
Molecular formula(分子式): c22h30cl2n10
Molecular weight(分子量): 505.45
EINECS No(EINECS号).: 200-238-7
Melting point(熔点):134-136°C(lit.)
Boiling point(沸点):641.45°C(roughestimate)
Density(密度):1.1555(roughestimate)
Refractive index(折射率):1.6300(estimate)
Storage condition(储存条件):Storebelow+30°C.
Solubility(溶解度):water:soluble0.08%at20°C
Acidity coefficient(酸度系数(pKa):pKa10.78(Uncertain)
Form(形态):neat
Water solubility(水溶解性):0.08Chemicalbookg/100mL(20ºC)Merck:13,2108BRN:2826432
Stability(稳定性)
:Stable.Incompatiblewithstrongoxidizingagents.InChIKey:GHXZTYHSJHQHIJ-UHFFFAOYSA-NCAS
Database(数据库):55-56-1(CASDataBaseReference)EPA
Chemical information(化学物质信息):Chlorhexidine(55-56-1)

Method of application:


In application, it can be prepared into water solution or alcohol solution, and the target can be achieved after the treated substance contacts the solution for several minutes. The concentration of aqueous solution (distilled water or deionized water) or alcohol solution is generally 0.015% to 0.15%. According to different application purposes, it can be prepared into other concentration solutions or other dosage forms.

Packaging and storage:

packing25kg / barrel, 5kg / box.

Storagesealed.

Safety and protection:

This product is not compatible with soap and potassium iodide. 0.05% concentration of this product is not allowed to be compatible with borax, bicarbonate, carbonate, oxide, citrate, phosphate and sulfate, because the salt with low solubility can be formed and precipitated after 24 hours.
 
 
 
matters needing attention
 
 
 
Avoid contact with eyes.
 
In case of cork (cork), the drug activity may be lost.
 
It can not be mixed with soap, alkali, tincture of iodine, potassium permanganate, mercuric oxide or washing powder. Because it has antagonistic effect with anionic surfactant, it is not suitable for sterilization.
 
It can not be used for aseptic treatment of surgical instruments.
 
Because it can't kill hepatitis B virus, Mycobacterium tuberculosis and spore, it can't be used to disinfect feces, sputum and other excreta and secretions.
 
Avoid chemical book and avoid high concentration drugs.
 
It is forbidden to use this product in allergic patients, anterior teeth filling patients (permanent coloring) and periodontitis patients (may increase calculus on gingiva). Patients aged 10-18 should not use gargle
 
The needle and tube soaked in this product must be rinsed with clear water before spinal cord puncture.
 
The aqueous solution of 1% chlorhexidine acetate is not stable, and white precipitate will be precipitated after placing. Generally, acetate of this product is used to prepare ointment and gluconate can be used to prepare solution.

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